Publications

Latest Publications

Performance Evaluation of the New Accelerator Mass Spectrometer at Accium BioSciences.

Radiocarbon, Zoppi U, Crye J, Song Q, Arjomand A. Vol 49, Nr1, 2007, p 171-180

Ali Arjomand, Ph.D.

President and Chief Operating Officer, Accium BioSciences

Ph.D. Dissertation A. Arjomand (1998) New Approaches for Studying Nutrient Kinetics in Humans: Folic Acid, Accelerator Mass Spectrometry and Mathematical Modeling. University of California, Davis and Lawrence Livermore National Laboratory.

Refereed Papers

Lin Y, Dueker SR, Follett JR, Fadel JG, Arjomand A, Schneider PD, Miller JW, Green R, Buchholz BA, Vogel JS, Phair RD, Clifford AJ. Quantitation of in vivo human folate metabolism. Am J Clin Nutr. 2004 Sep;80(3):680-91

Au TV, So-Lui MC, Zhang Y, Arjomand A, Lin Y, Dueker SR, Ho YK, Clifford AJ. Tissue folate binding protein levels in transgenic mice with tumors and in non-transgenic controls. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 May;123(1):45-52.

Buchholz BA, Arjomand A, Dueker SR, Schneider PD, Clifford AJ, Vogel JS. Intrinsic erythrocyte labeling and attomole pharmacokinetic tracing of 14C-labeled folic acid with accelerator mass spectrometry. Anal Biochem. 1999 May 1;269(2):348-52.

Clifford AJ, Arjomand A, Dueker SR, Schneider PD, Buchholz BA, Vogel JS. The dynamics of folic acid metabolism in an adult given a small tracer dose of 14C-folic acid. Adv Exp Med Biol. 1998;445:239-51.

Ugo Zoppi, Ph.D.

Director, AMS Laboratory, Accium BioSciences

Ph.D. Thesis U. Zoppi (1993) Isobar suppression in Accelerator Mass Spectrometry, Diss. ETH #10373, Swiss Federal Institute of Technology, Zurich

Book Chapters

C. Tuniz, U. Zoppi and M. Barbetti (2000) AMS dating in archaeology, history and art. in: Radiation in Art and Archeometry, D.C. Creagh and D.A. Bradley editors, Elsevier Science B.V., Amsterdam, 444-471.

C. Tuniz, U. Zoppi and M. Barbetti (2004) Radionuclide dating in archaeology by Accelerator Mass Spectrometry, Proceedings of the international school of physics 'Enrico Fermi' Course CLIV, M. Martini, M. Milazzo and M. Piacentini (Eds.), IOS Press, Amsterdam, 385-405.

Refereed Papers

D. David, J. Crouch and U. Zoppi (2005) Historicizing the spiritual: Bu shell arrangements on The Island of Badu, Torres Strait, Cambridge Archaeological Journal 15, 71-91.

C. Principe, J.C. Tanguy, S. Arrighi, A. Paiotti, M. Le Goff, and U. Zoppi (2004) Chronology of the Vesuvius activity from AD 79 to 1631 based on archaeomagnetism of lavas and historical sources. Bulletin of Vulcanology 66, 703-724.

D. Fink, M. Hotchkis, Q. Hua, G. Jacobsen, A. M. Smith, U. Zoppi, D. Child, C. Mifsud, H. van der Gaast, A. Williams and M. Williams (2004) The ANTARES AMS facility at ANSTO, NIM B 223-224, 109-115.

Q. Hua, M. Barbetti and U. Zoppi (2004) Radiocarbon in annual tree-rings from Thailand during the prebomb period, AD 1938-1954, Radiocarbon 46, 925-932.

Q. Hua, U. Zoppi, A.A. Williams and A.M. Smith (2004) Small-mass AMS radiocarbon analysis at ANTARES, NIM B 223-224, 284-292.

Q. Hua, M. Barbetti, U. Zoppi, D. Fink, M. Watanasak and G.E. Jacobsen (2004) Radiocarbon in tropical tree-rings during the Little Ice Age, NIM B 223-224, 489-494.

Q. Hua, C. Woodroffe, M. Barbetti, S. Smithers, U. Zoppi and D. Fink (2004) Marine reservoir corrections for the Cocos (Keeling) Islands, Indian Ocean, Radiocarbon 46, 603-610.

S. Bourke, U. Zoppi , J. Meadows, Q. Hua and S. Gibbins (2004) The end of the Chalcolithic period in the South Jordan valley: new 14C determinations from Teleilat Ghassul, Jordan, Radiocarbon 46, 315-323.

D. Bowman, B. Cook and U. Zoppi (2004) Holocene boundary dynamics of a northern Australia monsoon forest patch inferred from isotopic analysis of carbon (14C and d13C), and nitrogen (d15N) in soil organic matter, Austral Ecology 29, 605-612.

D. Bowman, B. Sharp and U. Zoppi (2004) Isotopic (13C and 14C) evidence supporting the transformative effect of cattle on north Australian vegetation, Journal of Biogeography 31, 1373–1375.

S. Bourke, E. Lawson, Q. Hua and U. Zoppi (2004) The Chronology of the late Neolithic and early Chalcolitic periods in the North Jordan Valley: new C14 dates from Pella in Jordan, in Radiocarbon and Archaeology, T. Higham, C. Bronk Ramsey and C. Owen (Eds.), Oxford University School of Archaeology Monograph 62, Oxford, 119-125.

M. Barbetti, Q. Hua, U. Zoppi, D. Fink, Y. Zhao and B. Thomson (2004) Radiocarbon variations from the southern hemisphere, 10,350 – 9,700 cal BP, NIM B 223-224, 366-370.

U. Zoppi, B. David, M. Wilson, Q. Hua, A. Williams and A. Watchman (2004) AMS radiocarbon dating of micro samples from the rock paintings of Malakula (Vanuatu), in Radiocarbon and Archaeology, T. Higham, C. Bronk Ramsey and C. Owen (Eds.), Oxford University School of Archaeology Monograph 62, Oxford, 73-82.

U. Zoppi, Z. Skopec, J. Skopec, G. Jones, D. Fink, Q. Hua, G. Jacobsen and A. Williams (2004) Forensic applications of 14C bomb-pulse dating, NIM B 223-224, 770-775.

U. Zoppi, M. Barbetti, R. Fletcher, Q. Hua, R.K. Chhem, C. Pottier and M. Watanasak (2004) The contribution of 14C AMS dating to the Greater Angkor archaeological project, NIM B 223-224, 681-685.

C. Tuniz, U. Zoppi and M. Hotchkis (2004) Sherlock Homes counts the atoms, accepted for publication in NIM B 213, 469-475.

L. Sbaffi, F. C. Wezel, G. Curzi and U. Zoppi (2004) Millennial to centennial scale palaeoclimatic variations during Termination I and the Holocene in the central Mediterranean Sea, Global and Planetary Change 40, 201-217.

Q. Hua, M. Barbetti, U. Zoppi, D.M. Chapman and B. Thomson (2003) Bomb radiocarbon in tree-rings from northern New South Wales, Australia: Implications for dendrochronology, atmospheric transport and air-sea exchange of CO2, Radiocarbon 45 431-447.

C. Tuniz, U. Zoppi and M. Hotchkis (2003) Sherlock Homes conta gli atomi, Sapere 1025, 63-69.

K.J. Harle, H. Heijnis, R. Chisari, A.P. Kershaw, U. Zoppi and G. Jacobsen (2002) A chronology for the long pollen record from Lake Wangoom, western Victoria (Australia) as derived from uranium/thorium disequilibrium dating, Journal of quaternary Science 17, 707-720.

R. Serandrei Barbero, A. Lezziero, A. Albani and U. Zoppi (2001) Depositi tardo-pleistocenici edolocenici nel sottosuolo veneziano: paleoambienti e cronologia, Il Quaternario (Italian Journal of Quaternary Sciences) 14, 9-22.

I.J. McNiven, I. Thomas and U. Zoppi (2001) Fraser Island archaeological project (FIAP): Background, aims and preliminary results of excavations at Waddy Point 1 rockshelter, Queensland Archaeological Research 13,

Q. Hua, G.E. Jacobsen, U. Zoppi, E.M. Lawson, A.A. Williams, A.M. Smith and M.J. McGann (2001) Progress in radiocarbon target preparation at the ANTARES AMS centre, Radiocarbon 43(2A), 275-282.

S. Bourke, E. Lawson, J. Lovell, Q Hua, U. Zoppi and M. Barbetti (2001) The chronology of the Ghassulian chalcolithic period in the southern Levant: new 14C determinations from Teleilat Ghassul, Jordan, Radiocarbon 43(3), 1217-1222.

U. Zoppi, A. Albani, A.J. Ammerman, Q. Hua, E.M. Lawson and R. Serandrei Barbero (2001) Preliminary estimate of the reservoir age in the Lagoon of Venice, Radiocarbon 43(2A), 489-494.

U. Zoppi, A Sagona, R. Siegele, Q. Hua, G. Jacobsen and E.M. Lawson (2001) The interpretation of archaeological dates from an AMS perspective, Research in Anthropology and Linguistics 5, 465-474.

U. Zoppi (2001) I documenti Miccinelli: il contributo offerto dalle analisi radiometriche, in Guaman Poma y Blas Valera - Tradición Andina e Historia Colonial, edited by Francesca Cantù, Antonio Pellicani Editore, Rome, 171-179.

U. Zoppi , E. Fulcheri, F.M. Gambari, Q. Hua, E.M. Lawson, M. Micheletti Cremasco and M. Venturino Gambari (2001) The Copper Age in northern Italy, Radiocarbon 43(2B), 1049-1056.

A.M. Smith, V.A. Levchenko, D.M. Etheridge, D.C. Lowe, Q. Hua, C.M. Trudinger, U. Zoppi and Elcheikh (2000) In search of in-situ radiocarbon in Law Dome ice and firn, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 172, 610-622

Q. Hua, M. Barbetti, G.E. Jacobsen, U. Zoppi and E.M. Lawson (2000) Bomb radiocarbon in annual tree rings from Thailand and Australia, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 172, 359-365

E.M. Lawson, G. Elliott, J. Fallon, D. Fink, M.A.C. Hotchkis, Q. Hua, G.E. Jacobsen, P. Lee, A.M. Smith, C. Tuniz and U. Zoppi (2000) AMS at ANTARES - The first 10 years, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 172, 95-99

U. Zoppi, Q. Hua, G. Jacobsen, G. Sarkissian, E.M. Lawson, C. Tuniz and L. Laurencich Minelli (2000) AMS and controversies in history: The Spanish conquest of Peru, Nucl. Instr. and Meth. B172, 756-760.

K. Kobayashi, S. Hatori, U. Zoppi, C. Nakano, Y. Sunohara, H. Nagai, K. Yoshida, M. Imamura, S. Shibata, H. Matsuzaki, M. Tanikawa, M. Murayama, Y. Aramaki, M. Sakamoto, T. Saitoh and H. Ohashi (1997) Current status of the AMS system at the University of Tokyo, Nucl. Instr. And Meth. B123, 107-111.

U. Zoppi, H. Matsuzaki, K. Kobayashi, M. Imamura, H. Nagai, S. Hatori, C. Nakano and Y. Sunohara (1997) New interpretation of the 10Be and 26Al content in cosmic spherules, Nucl. Instr. and Meth. B123, 319-323.

U. Zoppi, P.W. Kubik, M. Suter, H.A. Synal, H.R. von Gunten and D. Zimmermann (1994) High intensity isobar separation at the Zürich AMS facility, Nucl. Instr. and Meth. B92, 142-145.

U. Zoppi, M. Suter and H.A. Synal (1994) Isobar Separation with Gas Ionization Counters in Accelerator Mass Spectrometry, Nucl. Instr. and Meth. B89, 262-265.

Other Key AMS Publications

	Accelerator mass spectrometry for quantitative in vivo tracing. J.S. Vogel, BioTechniques 38:S25-S29 (2005)

	Guidance for Industry, Investigators, and Reviewers - Exploratory IND Studies (DRAFT GUIDANCE) U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER) Pharmacology/Toxicology (April 2005)

	A Small Dose in Time... I. Wilding, C. Garner, Good Clinical Practice Journal, Vol. 11, No.5 (2005)

	Human Microdosing – A Revolution in Early Clinical Development. P. Clewlew, European Pharmaceutical Contractor (2004)

	*Quantitation of in vivo* human folate metabolism.** Y. Lin, S.R. Dueker, J.R. Follett, J.G. Fadel, A. Arjomand, P.D. Schneider, J.W. Miller, R. Green, B.A. Buchholz, J.S. Vogel, R.D. Phair, A.J. Clifford. American Journal of Clinical Nutrition. 80(3):680-91 (2004)

	Evaluation of Microdosing Strategies for Studies in Preclinical Drug Development: Demonstration of Linear Pharmacokinetics in Dogs of a Nucleoside Analog over a 50-Fold Dose Range. P. Sandhu, J.S. Vogel, M.J. Rose, E.A. Ubick, J.E. Brunner, M.A. Wallace, J.K. Adelsberger, M.P. Baker, P.T. Henderson, P. Pearson, and T.A. Baillie, Drug Metabolism and Disposition, Vol. 32, No. 11:1254–1259 (2004)

	Big physics, small doses: the use of AMS and PET in human microdosing of development drugs. G. Lappin and C. Garner, Nature Reviews - Drug Discovery, Vol.2: 233-240 March (2003)

	Early Human Microdosing to Reduce Attrition in Clinical Drug Development. N. Sarapa. American Pharmaceutical Outsourcing, September/October (2003)

	Evaluation of Accelerator Mass Spectrometry in a Human Mass Balance and Pharmacokinetics Study, R. C. Garner, I. Goris, A. A. E. Laenen, E. Vanhoutte, W. Meuldermans, S. Gregory, J. V. Garner, D. Leong, M. Whattam, A. Calam, and C. A. W. Snel, Drug Metabolism and Disposition, Vol. 30, No. 7 (2002)

	A validation study comparing accelerator MS and liquid scintillation counting for analysis of ¹⁴C-labelled drugs in plasma, urine and faecal extracts. R.C. Garner, J. Barker, C. Flavell, J.V. Garner, M. Whattam, G.C. Young, N. Cussans, S. Jezequel, D. Leong, Journal of Pharmaceutical and Biomedical Analysis 24: 197–209 (2000)

	Bioanalytical Applications of Accelerator Mass Spectrometry for Pharmaceutical Research. K.W. Turteltaub and J.S. Vogel, Current Pharmaceutical Design, 6, 991-1007 (2000)

	Intrinsic Erythrocyte Labeling and Attomole Pharmacokinetic Tracing of ¹⁴C-Labeled Folic Acid with Accelerator Mass Spectrometry. B.A. Buchholz, A. Arjomand, S.R. Dueker, P.D. Schneider, Analytical Biochemistry 269, 348–352 (1999)

	The dynamics of folic acid metabolism in an adult given a small tracer dose of ¹⁴C-folic acid. A.J. Clifford, A. Arjomand , S.R. Dueker, P.D. Schneider, B.A. Buchholz, J.S. Vogel. Advances in Experimental Medicine and Biology, 445:239-51 (1998)